If you've e-mailed me in the past couple weeks and not gotten a response, I apologize — I'm rather snowed under with e-mail right now. I haven't forgotten about you, promise. I'm not yet at e-mail bankrupcy level, thankfully. I think a lot of it will be solved by unsubscribing from or filtering a bunch of mailing lists I'm on; there's some serious triage that needs to happen in that area. But if you haven't heard back, that's why.
I manage my personal e-mail via Sup, more or less a console-based clone of GMail, which does a pretty good job of letting me wade through a couple hundred messages a day, though obviously it (and I!) have limits. What do you use?